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Temporomandibular Disorders’ (TMDs) etiology, assessment, and management have always been much debated in dentistry. Scientific knowledge in support of the biopsychosocial model of pain practice has grown over the last few decades, but dissemination and implementation of contemporary evidence-based practice in general dental practice has not been fully achieved.

Outside of the specialist orofacial pain field, dentistry based on out-dated and disproven concepts such as gnathological precepts still persists and has been reinforced by the use of electronic instruments that have debatable validity, sensitivity, specificity, and reliability.

Ultimately, this persistence of a biomedical gnathological conceptually driven care model leads to overtreatment and potential iatrogenic damage. Recent papers and some debates within some orofacial pain expert communities underlined the need to enhance the diffusion and implementation of contemporary evidence into general dental practice. A fundamental initial step of this process is to distil and chronicle contemporary evidence into evidence-based guidelines for general dental practice.

This lecture will begin from the available evidence and will introduce the “good practice keypoints” prepared by the INfORM/IADR (Manfredini et al., CRANIO 2025) to start constructing an agreed summary/guideline of these relevant to general dental practice.

Prof. Daniele Manfredini

Prof. Daniele Manfredini received his DDS from the University of Pisa, Italy in 1999, a MSc in Occlusion and Craniomandibular Disorders in 2001 from the same University, a PhD in Dentistry from the ACTA Amsterdam, The Netherlands, and a Post-Graduation Specialty in Orthodontics from the University of Ferrara, Italy. He achieved the Diplomate Status from the American Board of Orofacial Pain in 2021.

From 2006 to 2016, Daniele Manfredini has been Assistant Professor at the TMD Clinic, Department of Maxillofacial Surgery, University of Padova, Italy.

Since 2017, Daniele Manfredini has served as Professor at the School of Dentistry, Department of Medical Biotechnologies, University of Siena, Italy, where he holds teachings in Oral Physiology and in Clinical Gnathology. He is currently the Director of the Orofacial Pain Unit.

Daniele Manfredini authored more than 340 papers in the field of bruxism, orofacial pain, and temporomandibular disorders in journals indexed in the Medline database (Scopus H-index=66).

Since the first release of world rankings in 2013, Daniele Manfredini has been ranked in the top three experts in TMD and in bruxism by the agency ExpertScape. He has been listed in the top-ten of researchers in the whole dentistry by the Stanford University ratings in 2025.

He is Member and Coordinator of the Bruxism Consensus Panel within the International Association for Dental Research, which works on the updated definition and classification strategies for bruxism and for which he currently serves in the INfORM Board of Directors.

Since January 1st, 2024, Daniele Manfredini is the Editor-in-Chief of CRANIO: The Journal of Craniomandibular and Sleep Practice.